NovaSyn TGR Resin: A Versatile Support for Solid-Phase Peptide Synthesis
NovaSyn® TGR resin is a widely used solid support in peptide synthesis, particularly valuable for the synthesis of long and complex peptides. Developed by Merck Millipore (formerly Novabiochem), NovaSyn TGR stands for "Tentagel Resin" and is designed to combine the beneficial characteristics of both polystyrene and polyethylene glycol (PEG) polymers. This hybrid resin offers superior swelling properties and enhanced solvation, making it ideal for Fmoc-based solid-phase peptide synthesis (SPPS).
Key Features
High Loading Capacity: Typically around 0.2–0.3 mmol/g, NovaSyn TGR resin allows for substantial peptide yield while maintaining synthesis efficiency.
Enhanced Solvation: The PEG component of the resin provides a more hydrophilic environment, improving accessibility to reagents and reducing aggregation in long peptide chains.
Excellent Swelling Behavior: Swells well in both polar and non-polar solvents, ensuring optimal conditions for coupling reactions.
Low Non-Specific Binding: The PEG-like matrix minimizes unwanted side interactions during synthesis, leading to cleaner reactions and higher purity products.
Stable and Chemically Resistant: Compatible with standard SPPS protocols, including strong acids (e.g., TFA) and bases used in deprotection steps.
Applications
NovaSyn TGR resin is especially useful in the following scenarios:
Synthesis of Long Peptides: Reduces aggregation and steric hindrance, improving yield and purity.
Difficult or Hydrophobic Sequences: Its hydrophilic environment helps solubilize sequences prone to aggregation or poor solubility.
Peptidomimetics and Modified Peptides: Offers the flexibility needed for incorporating non-standard amino acids or chemical modifications.
Handling and Storage
Store NovaSyn TGR resin in a dry, airtight container at room temperature.
Avoid prolonged exposure to moisture and light.
Pre-swell the resin in an appropriate solvent (e.g., DMF or DCM) before use for optimal performance.
Conclusion
NovaSyn TGR resin represents a powerful tool in the field of peptide synthesis. Its hybrid polymer structure, combining the rigidity of polystyrene with the solvation power of PEG, enables the efficient and reliable production of complex peptides. Whether working on therapeutic peptides, research peptides, or custom syntheses, NovaSyn TGR delivers the performance and reliability needed for demanding synthesis tasks.
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